The cyclin A2 gene (CCNA2), which switches off after birth, has been found to be capable of restoring and distributing heart cells, as shown by researchers from Mount Sinai Hospital. Experiments showed that activation of CCNA through a viral vector promotes the formation of new functional heart tissues, opening up new possibilities for treating heart attacks and heart failure.
Participants in the experiment were of different ages: 21, 41, and 55 years old. It was found that heart cells of older individuals respond to therapy using cyclin A2, while young heart cells did not undergo activation. These results confirm the natural regenerative capabilities of young hearts.
Previously, scientists demonstrated heart recovery in pigs after a heart attack through CCNA2. The new study shows that this mechanism can be successfully applied to human cells as well. Activation of CCNA2 encourages heart cells to divide without losing maturity, paving the way for real recovery of heart muscle and transitioning from symptom treatment to full restoration.
Scientists have found that the CCNA2 gene may be the key to restoring and strengthening heart muscle after a heart attack, which opens up new prospects for treating heart diseases in individuals of all ages.