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Social Isolation During COVID-19 Lockdowns Accelerated Biological Aging in 14-16 Year-Old Adolescents

Під час локдаунів COVID-19 підлітки 14-16 років зіткнулися з наслідками ізоляції, що вплинули на їхнє фізичне старіння. Photo: НВ — Техно

COVID-19 Lockdowns Linked to Faster Biological Aging in Teenagers Due to Lack of Social Interaction

Published on: November 6, 21:12

A study conducted by the Max Planck Institute of Psychiatry in Munich has revealed that the social restrictions imposed during the COVID-19 pandemic significantly sped up biological aging in adolescents aged 14 to 16. This acceleration was primarily driven by reduced social contact during a crucial stage of puberty. The findings were published in the Proceedings of the National Academy of Sciences (PNAS).

Study Details

The research involved over 1,000 participants from Germany. Scientists used an epigenetic clock, which measures DNA methylation changes, to assess biological aging. Saliva samples were collected before the first lockdown in March 2020 and again after the second wave of restrictions in spring 2022. While accelerated aging was observed across all age groups, teenagers between 14 and 16 experienced the most pronounced effects, linked to the lack of social engagement.

Strict lockdown measures negatively affected gene activity in adolescent cells, especially among those who had pre-existing health issues or lived in challenging environments prior to 2020. Interestingly, official COVID-19 infection rates in the cities studied had little impact on participants’ internal anxiety levels.

“Adolescence is a particularly vulnerable period. The severe restrictions disrupted socialization during a critical phase of psychological development, triggering a profound biological response.”

Alicia Schove

Experts warn that this hastened epigenetic aging increases the risk of developing serious illnesses later in life, including cancer and type 2 diabetes. Elizabeth Binder emphasized that an accelerated epigenetic clock is linked to greater susceptibility to these chronic conditions in adulthood.

These results highlight the significant health consequences of pandemic-related lockdowns on teenagers, underscoring the urgent need for further research and targeted support programs. Understanding how social deprivation during critical growth periods affects biological and mental health can guide future efforts to mitigate long-term risks for young people worldwide.

The impact of lifestyle choices on biological health has become increasingly evident, as seen in recent studies. For instance, research suggests that reducing caloric intake can lead to a decrease in DNA mutations, particularly in liver cells. This highlights the intricate relationship between diet and genetic stability, further emphasizing the importance of maintaining healthy habits during critical developmental periods.