How Night Shift Work Affects Brain Health: New Findings
A team of researchers from Singapore has uncovered a connection between night shift employment and reduced volume in specific brain structures. Their analysis, which drew on MRI scans and medical records from 14,198 individuals, found a modest decrease in the size of the right thalamus and left amygdala among those who worked rotating or overnight shifts. This investigation was conducted as part of the UK Biobank project, and the results point to possible neurological risks for shift workers.
The study focused on middle-aged and older adults who had no major pre-existing health conditions. Out of the 14,198 participants, 2,122 had experience working night shifts. To ensure accuracy, the scientists adjusted for several variables during their analysis, including:
- age
- sex
- circadian rhythm patterns
- other potentially confounding factors
“A reduction in thalamus and amygdala volume may serve as an early indicator of heightened vulnerability in the nervous system.”
Thomas Welton, neuroscientist
Interestingly, the structural changes in the brain appeared to partially reverse within about two years after individuals stopped working night shifts. This discovery could have significant implications for understanding how overnight work impacts employee health. The findings were published on June 2, 2026, and were reported by Science Alert.
These results highlight the urgent need for more thorough research into the health effects of night shift work, as reduced brain volume in certain regions may signal potential neurological harm. With millions of people worldwide working nonstandard hours, this issue is becoming increasingly relevant in today's work environment.